Role of PhenobaRbitone as an antiePilePtic DRug in 21st centuRy
نویسندگان
چکیده
The pharmacotherapy of epilepsy has greatly expanded with the introduction of several anti-convulsants in the last 2-3 decades. Yet phenobarbitone, the first effective anti-convulsant in neurological practice continues to be the most commonly prescribed drug for epilepsy. In spite of a century long experience with phenobarbitone, several controversies exist regarding its efficacy and tolerability. The latter is particularly contributed by declining commercial interest and physician bias. In this chapter we pay tribute to this oldest existing anti-convulsant and review the scientific literature on the existing knowledge of the role of phenobarbitone as an anti-epileptic drug in the 21st century.
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تاریخ انتشار 2012